R7632

Retinol

synthetic, ≥95% (HPLC), (Powder or Powder with Lumps)

• 동의어(들): Axerophthol, Vitamin A, Vitamin A alcohol, Vitamin A₁, all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
• 실험식(Hill 표기법): C₂₀H₃₀O
• CAS Number: 68-26-8
• Molecular Weight: 286.45
• Beilstein: 403040
• EC Number: 200-683-7
• MDL number: MFCD00001552
• UNSPSC 코드: 12352205
• eCl@ss: 34058018
• PubChem Substance ID: 24899395
• NACRES: NA.79

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 형태: (Powder or Powder with Lumps)
• 특이 활성도: ~2700 U/mg
• 기술: HPLC: suitable
• 색상: yellow to very dark yellow, to Very Dark Orange
• mp: 61-63 °C (lit.)
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1
• InChI: 1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
• InChI key: FPIPGXGPPPQFEQ-OVSJKPMPSA-N

설명

일반 설명

Retinol or vitamin A alcohol is the main circulating form of vitamin A. It is not biologically active. Retinol or all-trans-retinol is a 20-carbon molecule with cyclohexenyl ring, a side chain with four double bonds (in trans configuration), and an alcohol end group.

애플리케이션

Retinol has been used:

• for the synthesis of all-trans-retinoic acid in HepG2 cells
• to study the effect of retinol on the growth of murine normal colonic cells cultured as organoids
• as a standard for determination of vitamin A in cells
• as a component of chemically defined medium for testis organ culture and spermatogenesis in vitro.

생화학적/생리학적 작용

Retinol and its derivatives exhibit anti-aging properties. In addition, it also acts as an anti-wrinkle agent. However, due to its photoinstability and skin irritation potency, it is not widely used in cosmetic formulations. Retinol is used in the treatment of dermatoses including photoaging. Its deficiency is associated with the development of xerosis and follicular hyperkeratosis.

Retinol works as a precursor of active retinoids. It is converted to retinaldehyde and subsequently to retinoic acid. All-trans and 9-cis-retinoic acid are the ligands for nuclear receptors, retinoic acid receptors (RARs) and retinoid X receptors (RXRs). These receptors are transcriptional regulators of various genes.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

Light protecting glass vial.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H317,H319,H360FD,H413
• 예방조치 성명서: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves