R3375

Retinyl palmitate

Type IV, ~1,800,000 USP units/g, oil

• 동의어(들): Vitamin A palmitate, all−trans−Retinol palmitate
• 실험식(Hill 표기법): C₃₆H₆₀O₂
• CAS Number: 79-81-2
• Molecular Weight: 524.86
• Beilstein: 1917366
• EC Number: 201-228-5
• MDL number: MFCD00019414
• UNSPSC 코드: 12352205
• PubChem Substance ID: 24899361
• NACRES: NA.79

속성

• 생물학적 소스: synthetic (organic)
• 유형: Type IV
• 분석: ≥90% (HPLC)
• 형태: oil
• 특이 활성도: ~1,800,000 USP units/g
• 색상: yellow to orange
• mp: 26 °C
• 저장 온도: 2-8°C
• SMILES string: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
• InChI: 1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
• InChI key: VYGQUTWHTHXGQB-FFHKNEKCSA-N

설명

일반 설명

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A, respectively. The retinoids comprise a cyclohexenyl ring with a 20-carbon with double bonds in cis and trans configuration. Retinyl palmitate is a major storage form of vitamin A. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

애플리케이션

Retinyl palmitate has been used as:

• a retinoid derivative to modulate expression of connexin Cx26 and Cx30 in the cochlea
• a standard in high performance liquid chromatography(HPLC)
• as a retinoid substrate in the isomerase assay of eyecup protein homogenates

생화학적/생리학적 작용

Retinoids are ligands to nuclear receptors and have antioxidant functionality. Retinyl palmitate is widely used in pharmaceutical and cosmetic applications. In sunscreen, it protects from UVB-induced DNA damage and apoptosis. Retinyl palmitate is used to treat photoaging in skincare cosmetics. Retinyl palmitate is an effective chemopreventive agent to treat lung cancer. It also regulates various biological processes including cell differentiation and proliferation.

Review: Vitamin A metabolism.

포장

Sealed ampule.

물리적 형태

Oil at room temperature

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360D,H412
• 예방조치 성명서: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Aquatic Chronic 3 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point (°F): No data available
• Flash Point (°C): No data available
• 개인 보호 장비: Eyeshields, Gloves, type ABEK (EN14387) respirator filter