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Merck
모든 사진(2)

주요 문서

C2505

Sigma-Aldrich

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

동의어(들):

11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

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About This Item

실험식(Hill 표기법):
C21H30O4
CAS Number:
Molecular Weight:
346.46
Beilstein:
2339601
EC Number:
MDL number:
UNSPSC 코드:
51111800
PubChem Substance ID:
NACRES:
NA.77

제품명

Corticosterone, ≥92%

생물학적 소스

synthetic (organic)

Quality Level

분석

≥92%

양식

powder

mp

179-183 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

배송 상태

ambient

저장 온도

room temp

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

유전자 정보

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Corticosterone has been used:
  • in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
  • as a stress inducing hormone in pregnant mice
  • to test its effect on depression-related behaviors in mice

생화학적/생리학적 작용

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.
Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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문서 라이브러리 방문

Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)
Amy E M Newman et al.
The Journal of comparative neurology, 518(18), 3662-3678 (2010-07-24)
Chronic elevations in glucocorticoids can decrease the production and survival of new cells in the adult brain. In rat hippocampus, supraphysiological doses of dehydroepiandrosterone (DHEA; a sex steroid precursor synthesized in the gonads, adrenals, and brain) have antiglucocorticoid properties. With
Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease
Dufour BD and McBride JL
Experimental neurology, 283(9), 308-317 (2016)
Chronic stress alters concentrations of corticosterone receptors in a tissue-specific manner in wild house sparrows (Passer domesticus)
Lattin CR and Romero LM
The Journal of Experimental Biology, 217(14), 2601-2608 (2014)
Corticosterone production during repeated social defeat causes monocyte mobilization from the bone marrow, glucocorticoid resistance, and neurovascular adhesion molecule expression
Niraula A, et al.
The Journal of Neuroscience, 38(9), 2328-2340 (2018)

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