C2755

Cortisone

≥95%

• 동의어(들): 17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa
• 실험식(Hill 표기법): C₂₁H₂₈O₅
• CAS Number: 53-06-5
• Molecular Weight: 360.44
• Beilstein: 1356062
• EC Number: 200-162-4
• MDL number: MFCD00003610
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278304
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 무균: non-sterile
• 분석: ≥95%
• 양식: powder
• 기술: inhibition assay: suitable
• mp: 223-228 °C (dec.) (lit.)
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
• InChI key: MFYSYFVPBJMHGN-ZPOLXVRWSA-N
• 유전자 정보: human ... SERPINA6(866)

설명

애플리케이션

Cortisone has been used:

• to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor
• to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone
• in the determination of rates of cortisol oxidation by 11βHSD

생화학적/생리학적 작용

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration. Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.

Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na²⁺ retention potency.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

안전성 정보

• 픽토그램: GHS08
• 신호어: Warning
• 유해 및 위험 성명서: H361d
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)