C4895

Cephalexin hydrate

first-generation cephalosporin antibiotic

• 실험식(Hill 표기법): C₁₆H₁₇N₃O₄S · xH₂O
• CAS Number: 1820673-23-1
• Molecular Weight: 347.39 (anhydrous basis)
• Beilstein: 965503
• EC Number: 239-773-6
• MDL number: MFCD00056877
• UNSPSC 코드: 51282503
• PubChem Substance ID: 24278316
• NACRES: NA.85

속성

• Quality Level: 200
• 양식: powder
• pKa: 5.2; 7.3
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 동작 모드: cell wall synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: S1C2N(C(=C(C1)C)C(=O)O)C(=O)[C@H]2NC(=O)[C@H](N)c3ccccc3.O
• InChI: 1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15?;/m1./s1
• InChI key: AVGYWQBCYZHHPN-FNOHQHCYSA-N

설명

일반 설명

Chemical structure: ß-lactam

애플리케이션

Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

생화학적/생리학적 작용

Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.

기타 정보

Storage of this product should be in airtight containers and protected from light.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334
• 예방조치 성명서: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves