C8145
Cefsulodin sodium salt hydrate
third-generation cephalosporin antibiotic
동의어(들):
7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C22H19N4NaO8S2 · xH2O
CAS Number:
Molecular Weight:
554.53 (anhydrous basis)
EC Number:
MDL number:
UNSPSC 코드:
51284140
PubChem Substance ID:
NACRES:
NA.85
추천 제품
Quality Level
양식
powder or crystals
항생제 활성 스펙트럼
Gram-negative bacteria
Gram-positive bacteria
동작 모드
cell wall synthesis | interferes
저장 온도
2-8°C
SMILES string
[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1
InChI
1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1
InChI key
REACMANCWHKJSM-DWBVFMGKSA-M
일반 설명
Chemical structure: ß-lactam
애플리케이션
Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier.
Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
생화학적/생리학적 작용
Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.
기타 정보
Keep container tightly closed in a dry and well-ventilated place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Danièle Joseleau-Petit et al.
Journal of bacteriology, 189(18), 6512-6520 (2007-06-26)
Growing bacterial L forms are reputed to lack peptidoglycan, although cell division is normally inseparable from septal peptidoglycan synthesis. To explore which cell division functions L forms use, we established a protocol for quantitatively converting a culture of a wild-type
M A Hornitzky et al.
FEMS microbiology letters, 198(1), 17-22 (2001-04-28)
The prevalence of complex Shiga toxin-producing Escherichia coli (STEC), i.e. STEC containing accessory virulence factors intimin (eaeA) and/or enterohaemorrhagic E. coli haemolysin (ehxA) and their serotypes were determined in diagnostic bovine faecal samples processed during a 3 months period. The
J P Basly et al.
International journal of radiation biology, 75(2), 259-263 (1999-03-11)
This paper reports experimental data on the ESR identification of four irradiated cephalosporins (cefpodoxime, cefsulodin, cefixime and ceftizoxime). Equations to describe the ESR curves versus the dose and storage time were developed using mathematical procedures. Limits of detection (LOD) and
Sujoy K Sarkar et al.
PloS one, 7(11), e48598-e48598 (2012-11-10)
The combination of antibiotics is one of the strategies to combat drug-resistant bacteria, though only a handful of such combinations are in use, such as the β-lactam combinations. In the present study, the efficacy of a specific sub-inhibitory concentration of
A Lehmacher et al.
Applied and environmental microbiology, 64(7), 2449-2453 (1998-07-02)
The presence of a hemolysin-encoding gene, elyA or hlyA, from Shiga toxin-producing Escherichia coli (STEC) was detected by PCR in each of 95 strains tested. PCR products of elyA from human STEC isolates of serovars frequently detected in Germany, such
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