C9393

Cloxacillin sodium salt monohydrate

β-lactamase-resistant antibiotic

• 동의어(들): Cloxacillin, Sodium cloxacillin monohydrate
• Linear Formula: C₁₉H₁₇ClN₃O₅SNa · H₂O
• CAS Number: 7081-44-9
• Molecular Weight: 475.88
• EC Number: 211-390-9
• MDL number: MFCD00150735
• UNSPSC 코드: 51102829
• PubChem Substance ID: 24893156
• NACRES: NA.85

속성

• 형태: powder or crystals
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 동작 모드: cell wall synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: O.[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
• InChI: 1S/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1
• InChI key: KCUWTKOTPIUBRI-VICXVTCVSA-M

설명

일반 설명

Chemical structure: ß-lactam

애플리케이션

Cloxacillin is effective against infections caused by penicillin G-resistant staphylococci. It was used in studies of topical antibacterial agents for burn and crush wounds.

생화학적/생리학적 작용

Cloxacillin is a semi-synthetic antibiotic and a chlorinated derivative of oxacillin. It inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin is often used as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H315,H317,H319,H334,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves