27555
Cloxacillin sodium salt
≥95.0% (HPLC)
동의어(들):
3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt, Syntarpen sodium salt
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H17ClN3NaO5S
CAS Number:
Molecular Weight:
457.86
Beilstein:
4103180
EC Number:
MDL number:
UNSPSC 코드:
51102829
PubChem Substance ID:
NACRES:
NA.85
추천 제품
생물학적 소스
semisynthetic
Quality Level
분석
≥95.0% (HPLC)
양식
powder or crystals
불순물
≤5% Total impurities (anhydrous)
색상
white to off-white
항생제 활성 스펙트럼
Gram-positive bacteria
동작 모드
cell wall synthesis | interferes
저장 온도
2-8°C
SMILES string
[Na+].Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C([O-])=O
InChI
1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1
InChI key
SCLZRKVZRBKZCR-SLINCCQESA-M
일반 설명
Chemical structure: ß-lactam
애플리케이션
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce β-lactamase. It is used to study the role of pH in antibiotic effectiveness and how oxgall, acid, and hydrogen peroxide stress effects the susceptibility of Bifidobacteria.
생화학적/생리학적 작용
Cloxacillin interferes with the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins. This inhibits the necessary cross-linking and leads to autolysis of the bacteria by autolysins.
기타 정보
Keep container tightly closed in a dry and well-ventilated place.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Farahnaz Pahlavanzadeh et al.
The Yale journal of biology and medicine, 93(1), 29-34 (2020-04-01)
Today, resistance to antibacterial agents is the most important problem facing public health. Pseudomonas aeruginosa is a common gram-negative bacterium and an important cause of nosocomial infections. Resistance to many antibiotics in strains of P. aeruginosa isolated from hospital settings
Sandrine Lemaire et al.
Antimicrobial agents and chemotherapy, 51(5), 1627-1632 (2007-02-20)
Early studies showed that methicillin-resistant Staphylococcus aureus (MRSA) strains are susceptible to beta-lactams when they are exposed to pH < or = 5.5 in broth. Because S. aureus survives in the phagolysosomes of macrophages, where the pH may be acidic
E Kheadr et al.
Antimicrobial agents and chemotherapy, 51(1), 169-174 (2006-10-25)
The effects of acid, oxgall, and H(2)O(2) on susceptibilities to antibiotics and nisin were examined for 13 strains of bifidobacteria. Susceptibilities to ampicillin, cloxacillin, penicillin, vancomycin, kanamycin, neomycin, paramomycin, streptomycin, chloramphenicol, erythromycin, tetracycline, and nisin A were assayed by a
M Britzi et al.
Journal of veterinary pharmacology and therapeutics, 37(5), 445-450 (2014-03-29)
The pharmacokinetics of ampicillin in dogs was determined after intravenous (i.v.) bolus and constant rate infusion. Ampicillin was administered to six beagle dogs as an i.v. bolus at 20 mg/kg and as a constant rate i.v. infusion (CRI) at 20 mg/kg during
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