C7897

Clonidine hydrochloride

solid

• 동의어(들): 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride
• 실험식(Hill 표기법): C₉H₉Cl₂N₃ · HCl
• CAS Number: 4205-91-8
• Molecular Weight: 266.55
• Beilstein: 4163525
• EC Number: 224-121-5
• MDL number: MFCD00036705
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277750
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 색상: white
• solubility: H₂O: soluble; methanol: soluble
• 주관자: Boehringer Ingelheim
• 저장 온도: 2-8°C
• SMILES string: Cl[H].Clc1cccc(Cl)c1NC2=NCCN2
• InChI: 1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
• InChI key: ZNIFSRGNXRYGHF-UHFFFAOYSA-N
• 유전자 정보: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

설명

일반 설명

Clonidine hydrochloride has antihypertensive analgesic and antidiarrheal properties. It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro. Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD), menopausal flushing, drug withdrawal and Tourette′s syndrome.

애플리케이션

Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist:

• in ex vivo leptin release assay
• to study its effects on pain hypersensitivity in 6-OHDA lesioned rats
• to study its influence on the sleep of larval zebrafish
• to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation

Clonidine hydrochloride has been used:

• to reduce central noradrenaline levels
• to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion
• to attenuate thermal and mechanical pain hypersensitivity in rats
• as a positive control for pertussis toxin (PTX)

생화학적/생리학적 작용

α₂-adrenoceptor agonist; I₁ imidazoline binding site ligand.

Clonidine hydrochloride is used for management of hypertension in pregnant women. In addition, it also acts as a therapeutic for neonatal abstinence syndrome. Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure.

특징 및 장점

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H330
• 예방조치 성명서: P301 + P310 + P330 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges