Y3125

Yohimbine hydrochloride

≥98% (HPLC), powder, α2-adrenergic receptor antagonist

• 동의어(들): 17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
• 실험식(Hill 표기법): C₂₁H₂₆N₂O₃ · HCl
• CAS Number: 65-19-0
• Molecular Weight: 390.90
• EC Number: 200-600-4
• MDL number: MFCD00012674
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277814
• NACRES: NA.77

속성

• 제품명: Yohimbine hydrochloride, ≥98% (HPLC), powder
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• mp: 288-290 °C (dec.) (lit.)
• solubility: H₂O: 10 mg/mL
• SMILES string: Cl.COC(=O)[C@H]1[C@@H](O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC12
• InChI: 1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1
• InChI key: PIPZGJSEDRMUAW-VJDCAHTMSA-N
• 유전자 정보: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

설명

애플리케이션

Yohimbine hydrochloride has been:

• used to study its in vitro antiviral, antibacterial and antifungal activities and cytotoxicity
• used as a tyramine receptor blocker to oppose the effects of increased tyramine in relation with flight initiation and maintenance deficits in experimental flies
• used alone and as well as with brimonidine to study the neuroprotective effect of brimonidine in the presence of glutamate-induced neurotoxicity, oxidative stress and hypoxia on in vitro cultures of purified rat retinal ganglion cells

생화학적/생리학적 작용

Yohimbine is derived from the Coryanthe yohimbe tree cortex. It is an alkaloid. Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenergic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure. It is useful in treating erectile dysfunction and promotes sexual functioning.

특징 및 장점

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H330
• 예방조치 성명서: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges