C9915

ω-Conotoxin GVIA

≥97% (HPLC)

• 실험식(Hill 표기법): C₁₂₀H₁₈₂N₃₈O₄₃S₆
• CAS Number: 106375-28-4
• Molecular Weight: 3037.35
• MDL number: MFCD00076620
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 구성: Peptide content, ~70%
• 저장 온도: −20°C
• 유전자 정보: human ... CACNA1B(774) ; mouse ... CACNA1B(12287) ; rat ... CACNA1B(257648)

설명

Amino Acid Sequence

Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 [Disulfide Bridges: 1-16, 8-19, 15-26]

애플리케이션

ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.

Powerful probe for exploring the vertebrate pre-synaptic terminal.

생화학적/생리학적 작용

ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.

Blocks specific voltage-dependent N-type Ca²⁺ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.

기타 정보

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)