D4628

Diethylstilbestrol

≥99% (HPLC)

• 동의어(들): (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene, DES, Stilbestrol
• 실험식(Hill 표기법): C₁₈H₂₀O₂
• CAS Number: 56-53-1
• Molecular Weight: 268.35
• Beilstein: 2056095
• EC Number: 200-278-5
• MDL number: MFCD00002373
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24893887
• NACRES: NA.77

속성

• 분석: ≥99% (HPLC)
• 형태: powder
• SMILES string: CC\C(c1ccc(O)cc1)=C(\CC)c2ccc(O)cc2
• InChI: 1S/C18H20O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h5-12,19-20H,3-4H2,1-2H3/b18-17+
• InChI key: RGLYKWWBQGJZGM-ISLYRVAYSA-N
• 유전자 정보: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) ; mouse ... Esr1(13982) ; rat ... Ar(24208) , Esr1(24890)

설명

애플리케이션

Diethylstilbestrol has been used:

• to evaluate the estrogenic activity of diethylstilbestrol by quantitating the expression levels of endogenous estrogen-regulated marker genes
• to evaluate the estrogenic, androgenic and toxicity responses in bioluminescent yeast bioreporter assay (BLYES)
• to detect its effect on the proliferation and tyrosinase activity of melanocytes

생화학적/생리학적 작용

Diethylstilbestrol is a synthetic estrogen with carcinogenic properties. Causes renal clear-cell carcinoma in Syrian hamster. In humans it causes increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. Used in the treatment of prostate cancer to block the production of testosterone.

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H315,H319,H335,H350,H360FD,H410
• 예방조치 성명서: P202 - P261 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges