E1253

Estriol

≥97%

• 동의어(들): 1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene
• 실험식(Hill 표기법): C₁₈H₂₄O₃
• CAS Number: 50-27-1
• Molecular Weight: 288.38
• Beilstein: 2508172
• EC Number: 200-022-2
• MDL number: MFCD00003691
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24894396
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 무균: non-sterile
• 분석: ≥97%
• 양식: powder
• mp: 280-282 °C (lit.)
• solubility: pyridine: 50 mg/mL, clear, colorless to faintly brownish-yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1C[C@@H](O)[C@@H]2O
• InChI: 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1
• InChI key: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• 유전자 정보: human ... SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208)

설명

애플리케이션

Estriol has been used as a sex hormone to determine its binding constants to insulin (INS), the insulin receptor (IR), and INS-like peptides derived from the IR.

생화학적/생리학적 작용

Estriol is a metabolite of 17β-estradiol with much lower biological activity. It is the primary estrogen found in the urine. Large quantities of estriol and estrone are produced by the placenta during pregnancy. These are also the primary estrogens produced by adipose tissue in men and post-menopausal women. Estriol may exhibit immunomodulatory benefits against various diseases such as autoimmune, inflammatory, and neurodegenerative conditions.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H351,H360FD,H362
• 예방조치 성명서: P201 - P202 - P260 - P263 - P264 - P308 + P313
• Hazard Classifications: Carc. 2 - Lact. - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges