D7000

Deoxycorticosterone acetate

• 동의어(들): 11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate
• 실험식(Hill 표기법): C₂₃H₃₂O₄
• CAS Number: 56-47-3
• Molecular Weight: 372.50
• Beilstein: 2570798
• EC Number: 200-275-9
• MDL number: MFCD00003660
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24894065
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 무균: non-sterile
• 분석: ≥98% (HPLC)
• 양식: powder
• solubility: H₂O: insoluble; acetone: soluble (1 in 30); alcohol: soluble (1 in 50); chloroform: freely soluble; dioxane: slightly soluble; vegetable oils: slightly soluble
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1
• InChI key: VPGRYOFKCNULNK-ACXQXYJUSA-N
• 유전자 정보: human ... NR3C2(4306)

설명

일반 설명

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone. It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity. It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.

애플리케이션

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy. It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)