추천 제품
생물학적 소스
bovine articular cartilage
Quality Level
형태
salt-free, lyophilized powder
분자량
~100 kDa
포장
glass bottle of 0.5 mg
기술
cell culture | mammalian: suitable
solubility
PBS: ≥2.00 mg/mL, clear, colorless to yellow
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
cow ... DCN(280760)
일반 설명
Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.
Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues. It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.
애플리케이션
Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA), binding assays, binding inhibition assay, parasite binding assays, scaffold fabrication, quartz crystal microbalance assay, inhibition of CSA (chondroitin sulphate A) binding assay and glycans and glycan biotinylation.
생화학적/생리학적 작용
Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis. Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.
기타 정보
Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain. From 0.2 μm filtered solution prior to lyophilization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
The chondroitin sulphate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.
Dahlback M, et al.
The Journal of Biological Chemistry (2011)
Xiaolei Wang et al.
Scientific reports, 7(1), 9672-9672 (2017-08-31)
Choroidal neovascularization(CNV) is the most severe complication in Age-related macular degeneration(AMD) and the most common cause of irreversible blindness in the elderly in developed world. The aim of this study was to identify the effect of transforming growth factor-β(TGF-β) and
Functional and immunological characterization of the var2CSA-DBL5? domain of a placental Plasmodium falciparum isolate.
Gangnard S, et al.
Molecular and Biochemical Parasitology, 173(2), 115-122 (2010)
Seda Duran G Ler et al.
Indian journal of ophthalmology, 69(2), 369-373 (2021-01-20)
The aims of this study were to evaluate the effects of decorin (DCN) in rat oxygen-induced retinopathy (OIR) model and to compare the results with those of bevacizumab. Twenty-eight newborn Sprague-Dawley rats were randomly divided into four groups. Group I
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
Clausen T M, et al.
The Journal of Biological Chemistry, 287(28), 23332-23345 (2012)
문서
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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