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Merck
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주요 문서

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D9696

Sigma-Aldrich

Dronedarone hydrochloride

≥98% (HPLC)

동의어(들):

N-{2-Butyl-3-[4-(3-dibutylaminopropoxy)benzoyl]benzofuran-5-yl}methanesulfonamide hydrochloride, Multaq, SR-33589B

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About This Item

실험식(Hill 표기법):
C31H44N2O5S · HCl
CAS Number:
141625-93-6
Molecular Weight:
593.22
MDL number:
MFCD00914940
UNSPSC 코드:
12352200
PubChem Substance ID:
329798909
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

형태

powder

저장 조건

desiccated

색상

white to off-white

solubility

DMSO: 15 mg/mL, clear

주관자

Sanofi Aventis

저장 온도

2-8°C

SMILES string

Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23

InChI

1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H

InChI key

DWKVCQXJYURSIQ-UHFFFAOYSA-N

유전자 정보

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , HCN4(10021) , KCNJ2(3759) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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애플리케이션

Dronedarone hydrochloride has been used as an anti-arrhythmic drug to assess its impact in P19C5 embryoid bodies (EBs). It has also been used to determine its antiviral potency.

생화학적/생리학적 작용

Dronedarone is a Class III antiarrhythmic and a multi-channel blocker for atrial fibrillation. It blocks potassium, sodium, and calcium channels and also exhibits antiadrenergic properties.
Dronedarone is a synthetic derivative of amiodarone, which belongs to the class of benzofurane anti-arrhythmic compounds. It might moderately block cytochrome P450 3A4 (CYP3A4) activity. Dronedarone is used to treat atrial flutter.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Jeremy A Schafer et al.
Cardiovascular therapeutics, 28(1), 38-47 (2010-01-16)
Atrial fibrillation (AF) is the most common sustained arrhythmia, affecting more than 2.2 million Americans. ACC/AHA/ESC guidelines for the management of patients with AF recommend amiodarone for maintaining sinus rhythm. Dronedarone is a derivative of amiodarone indicated for the treatment
Use of in vitro morphogenesis of mouse embryoid bodies to assess developmental toxicity of therapeutic drugs contraindicated in pregnancy
Warkus ELL, et al.
Toxicological Sciences, 149(1), 15-30 (2016)
Dronedarone: current evidence and future questions
Schafer JA, et al.
Cardiovascular Therapeutics, 28(1), 38-47 (2010)
Filovirus antiviral activity of cationic amphiphilic drugs is associated with lipophilicity and ability to induce phospholipidosis
Gunesch AP, et al.
Antimicrobial Agents and Chemotherapy (2020)
Stress degradation studies of dronedarone in pharmaceutical dosage form by a validated stability-indicating LC method
Ahirrao VK, et al.
Journal of the Chilean Chemical Society, 57(3), 1272-1276 (2012)
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