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주요 문서

COO/COA

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E2375

Emetine dihydrochloride

Name: Emetine dihydrochloride
Brand: SIGMA

동의어(들):

6′,7′,10,11-Tetramethoxyemetan dihydrochloride

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모든 사진(3)

About This Item

실험식(Hill 표기법):

C₂₉H₄₀N₂O₄ · 2HCl

CAS Number:

316-42-7

Molecular Weight:

553.56

MDL number:

MFCD00242944

UNSPSC 코드:

12352200

PubChem Substance ID:

24278410

NACRES:

NA.77

추천 제품

Slide 1 of 10

1 of 10

Sigma-Aldrich

SMB01061

Emetine

Millipore

324693

Emetine, Dihydrochloride

Sigma-Aldrich

A9789

Anisomycin from Streptomyces griseolus

Sigma-Aldrich

01810

Cycloheximide

E0100000

Emetine hydrochloride

Sigma-Aldrich

C7698

Cycloheximide

Sigma-Aldrich

D2650

Dimethyl sulfoxide

Sigma-Aldrich

D8418

Dimethyl sulfoxide

Sigma-Aldrich

T9033

Thapsigargin

Sigma-Aldrich

D6883

2′,7′-Dichlorodihydrofluorescein diacetate

Quality Level

100

항생제 활성 스펙트럼

parasites

동작 모드

protein synthesis | interferes

저장 온도

2-8°C

SMILES string

[H][C@@]12C[C@H](C[C@@]3([H])NCCC4=C3C=C(OC)C(OC)=C4)[C@@H](CC)CN1CCC5=C2C=C(OC)C(OC)=C5

InChI

1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1

InChI key

JROGBPMEKVAPEH-GXGBFOEMSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Emetine dihydrochloride has been used:

as a protein synthesis inhibitor to study its effects on human papillomavirus type 8 E2 protein half-life
to study its effects on the stress granules assembly
as a chain-elongation inhibitor in puromycin assay for protein synthesis

생화학적/생리학적 작용

Emetine dihydrochloride is a member of the ipecac alkaloids family. It can mediate inhibition of protein and nucleic acid synthesis. It exhibits antiviral activity against dengue virus infection and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Emetine dihydrochloride exhibits anti-proliferative effects against bladder cancer cells. It also possesses anti-protozoal activity.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

픽토그램

GHS06

신호어

Danger

유해 및 위험 성명서

H300,H315,H319

예방조치 성명서

P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 - P332 + P313

Hazard Classifications

Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 6

1 of 6

Sigma-Aldrich

SML0197

4E1RCat

Sigma-Aldrich

S6626

Strophanthidin

Sigma-Aldrich

E4632

Econazole nitrate salt

Sigma-Aldrich

P4405

Podophyllotoxin

Sigma-Aldrich

C2932

Chelerythrine chloride

Sigma-Aldrich

MABE343

Anti-Puromycin Antibody, clone 12D10

Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains.

Hiwa Målen et al.

BMC microbiology, 11, 18-18 (2011-01-26)

The potential causes for variation in virulence between distinct M. tuberculosis strains are still not fully known. However, differences in protein expression are probably an important factor. In this study we used a label-free quantitative proteomic approach to estimate differences

Antiviral activity of emetine dihydrochloride against dengue virus infection

Yin L J S, et al.

Journal of Antivirals & Antiretrovirals, 1, 062-000 (2009)

Intermittent fasting promotes prolonged associative interactions during synaptic tagging/capture by altering the metaplastic properties of the CA1 hippocampal neurons.

Ananya Dasgupta et al.

Neurobiology of learning and memory, 154, 70-77 (2017-12-27)

Metaplasticity is the inherent property of a neuron or neuronal population to undergo activity-dependent changes in neural function that modulate subsequent synaptic plasticity. Here we studied the effect of intermittent fasting (IF) in governing the interactions of associative plasticity mechanisms

Induction of apoptosis and changes in nuclear G-actin are mediated by different pathways: the effect of inhibitors of protein and RNA synthesis in isolated rat hepatocytes.

I Meijerman et al.

Toxicology and applied pharmacology, 156(1), 46-55 (1999-04-02)

Stressor-induced changes in the cytoskeleton, of which actin is a major component, may lead to apoptosis. The role of drug-induced changes in nuclear G-actin and apoptosis was studied in freshly isolated hepatocytes. Several protein synthesis inhibitors, cycloheximide, puromycin, and emetine

TDP-43 is recruited to stress granules in conditions of oxidative insult.

Claudia Colombrita et al.

Journal of neurochemistry, 111(4), 1051-1061 (2009-09-22)

Transactive response DNA-binding protein 43 (TDP-43) forms abnormal ubiquitinated and phosphorylated inclusions in brain tissues from patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. TDP-43 is a DNA/RNA-binding protein involved in RNA processing, such as transcription, pre-mRNA splicing

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문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

주요 문서

Emetine dihydrochloride

About This Item

추천 제품

속성

Quality Level

항생제 활성 스펙트럼

동작 모드

저장 온도

SMILES string

InChI

InChI key

설명

애플리케이션

생화학적/생리학적 작용

특징 및 장점

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

문서

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