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Merck
모든 사진(2)

주요 문서

E3520

Sigma-Aldrich

Ebselen

powder, ≥98% (TLC)

동의어(들):

2-Phenyl-1,2-benzisoselenazol-3(2H)-one

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About This Item

실험식(Hill 표기법):
C13H9NOSe
CAS Number:
Molecular Weight:
274.18
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77

제품명

Ebselen, cysteine modifier

Quality Level

분석

≥98% (TLC)

양식

powder

mp

176-182  °C

solubility

chloroform: 19.60-20.40 mg/mL, clear, yellow

저장 온도

2-8°C

SMILES string

O=C1N([Se]c2ccccc12)c3ccccc3

InChI

1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H

InChI key

DYEFUKCXAQOFHX-UHFFFAOYSA-N

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일반 설명

Ebselen is a sympathomimetic amine.

애플리케이션

Ebselen has been used as a:
  • voltage-dependent calcium channels (VDCCs) blocker
  • glutathione peroxidase mimetic to test its inhibitory effect on contraction-mediated deoxy glucose (2-DG) uptake in mouse

extensor digitorum longus (fast-twitch) muscle
  • glucocerebrosidase inhibitor
  • hepatitis C virus helicase inhibitor

생화학적/생리학적 작용

An organo-selenium compound possessing antioxidant properties. Inhibits mammalian lipoxygenases in the absence of thiol groups, and glutathione S-transferase and papain via the interaction with cysteine residues. Also inhibits indoleamine 2,3-dioxygenase by covalently modifying a cysteine residue, the effect being reversible with dithiothreitol. Inhibits oxidation of low density lipoproteins (LDL).
Ebselen, a glutathione-peroxidase-mimic, elicits anti-inflammatory activity. It also has anti-atherosclerotic functionality. Ebselen displays antibacterial action on) multidrug-resistant Staphylococcus aureus (MRSA) infections and could be a potential therapeutic target for treating MRSA based skin infection. It is regarded as neuroprotective agent and elicits chemopreventive functionality in inflammation-associated carcinogenesis.

픽토그램

Skull and crossbonesHealth hazardEnvironment

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening
Urban DJ, et al.
Combinatorial Chemistry & High Throughput Screening, 11(10), 817-824 (2008)
Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections
Thangamani S, et al.
Scientific reports, 5, 11596-11596 (2015)
Diana Islam et al.
American journal of respiratory and critical care medicine, 199(10), 1214-1224 (2018-12-07)
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS). Objectives: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS. Methods:
Lili Zou et al.
EMBO molecular medicine, 9(8), 1165-1178 (2017-06-14)
Multidrug-resistant (MDR) Gram-negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance. Here, we report that five most clinically difficult-to-treat MDR Gram-negative bacteria are highly sensitive to a
Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in Neonatal Cochlear Explants
Liang Q, et al.
Frontiers in Neuroscience, 13, 1073-1073 (2019)

문서

Uncover properties and applications of the cysteine protease papain and find inhibitors, substrates, and other papain products.

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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