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Merck
모든 사진(3)

Key Documents

E9406

Sigma-Aldrich

Epirubicin hydrochloride

≥90% (HPLC)

동의어(들):

4′-Epidoxorubicin hydrochloride, Epidoxorubicin hydrochloride

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About This Item

실험식(Hill 표기법):
C27H29NO11 · HCl
CAS Number:
Molecular Weight:
579.98
EC Number:
MDL number:
UNSPSC 코드:
51102829
PubChem Substance ID:
NACRES:
NA.85

생물학적 소스

synthetic

Quality Level

분석

≥90% (HPLC)

형태

powder

색상

red to deep red

solubility

H2O: soluble

항생제 활성 스펙트럼

neoplastics

동작 모드

DNA synthesis | interferes
enzyme | inhibits

저장 온도

−20°C

SMILES string

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22-,27-;/m0./s1

InChI key

MWWSFMDVAYGXBV-FGBSZODSSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

생화학적/생리학적 작용

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.
Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

픽토그램

Health hazardExclamation mark

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


시험 성적서(COA)

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