G8168

G418 disulfate salt

solution, non-animal origin, suitable for cell culture, BioReagent

• 동의어(들): Antibiotic G418
• 실험식(Hill 표기법): C₂₀H₄₀N₄O₁₀ · 2H₂SO₄
• CAS Number: 108321-42-2
• Molecular Weight: 692.71
• MDL number: MFCD00058314
• UNSPSC 코드: 12352207
• PubChem Substance ID: 24895333
• NACRES: NA.76

속성

• 제품명: G 418 disulfate salt solution, 50 mg/mL in H₂O, 0.1 μm filtered, BioReagent, suitable for cell culture
• 생물학적 소스: Micromonospora echinospora
• Quality Level: 200
• 무균: 0.1 μm filtered
• 제품 라인: BioReagent
• 양식: solution
• 효능: 50-60 mg per mL
• 분자량: 692.7
• 포장: pkg of 10 and 100 mL
• 농도: 50 mg/mL in H₂O
• 기술: cell culture | mammalian: suitable
• 불순물: endotoxin, tested
• 색상: colorless
• solubility: H₂O: 50 mg/mL, clear
• 항생제 활성 스펙트럼: parasites
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O
• InChI: 1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1
• InChI key: UHEPSJJJMTWUCP-NKCAIAFTSA-N

설명

일반 설명

Chemical structure: aminoglycoside

애플리케이션

G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.

생화학적/생리학적 작용

Mode of Action: G418 blocks polypeptide synthesis and protein elongation by inhibiting synthesis at the 70S and 80S ribosomes.

Antimicrobial Spectrum: G418 selects for cells stably transfected with an iNOS promoter construct and neomycin resistance gene and shows activity against protozoa and helminthes.

주의사항

The product is stable for two years when stored at 2-8°C.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H317,H334
• 예방조치 성명서: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable