추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
형태
liquid
농도
1 mg/mL
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... H1.0(3005)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.
생화학적/생리학적 작용
The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.
물리적 형태
Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
H1 histones: current perspectives and challenges
Harshman SW, et al.
Nucleic Acids Research, 41(21), 9593-9609 (2013)
Linker Histone in Diseases
Ye X, et al.
International Journal of Biological Sciences, 13(8), 1008-1018 (2017)
The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
Hergeth SP and Schneider R
EMBO Reports, 16(11), 1439-1453 (2015)
Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development
Hu J, et al.
Cell Death & Disease, 9(7), 765-765 (2018)
Histone H1 null vertebrate cells exhibit altered nucleosome architecture
Hashimoto H, et al.
Nucleic Acids Research, 38(11), 3533-3545 (2010)
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