추천 제품
생물학적 소스
synthetic (organic)
Quality Level
무균
non-sterile
분석
≥95%
양식
powder
solubility
chloroform: 50 mg/mL, clear, colorless to light yellow
배송 상태
ambient
저장 온도
room temp
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(C)=O
InChI
1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
InChI key
DBPWSSGDRRHUNT-CEGNMAFCSA-N
유전자 정보
human ... PGR(5241) , SERPINA6(866)
rat ... Ar(24208)
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일반 설명
17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase. 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid receptor.
애플리케이션
17α-Hydroxyprogesterone has been used:
- for titration against ovarian S9 protein in thin-layer chromatography
- as a substrate for hydroxysteroid dehydrogenase from B. megaterium cultures
- as a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)
생화학적/생리학적 작용
17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP. High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Aquatic Chronic 2 - Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
개인 보호 장비
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
이미 열람한 고객
Linder, N., et al.
Archives of Disease in Childhood. Fetal and Neonatal Edition, 81, 175-175 (1999)
Non-genomic progesterone actions in female reproduction
Gellersen B, et al.
Human Reproduction Update, 15(1) (2009)
Genetic engineering of Bacillus megaterium for high-yield production of the major teleost progestogens 17alpha, 20beta-di-and 17alpha, 20beta, 21alpha-trihydroxy-4-pregnen-3-one
Gerber A, et al.
Metabolic engineering, 36 (2016)
Influence of 17-hydroxyprogesterone, progesterone and sex steroids on mineralocorticoid receptor transactivation in congenital adrenal hyperplasia
Mooij CF, et al.
Hormone Research in p?diatrics, 83(6) (2015)
Valérie Leroy et al.
Journal of the American Society of Nephrology : JASN, 20(1), 131-144 (2008-11-07)
Besides its classical effects on salt homeostasis in renal epithelial cells, aldosterone promotes inflammation and fibrosis and modulates cell proliferation. The proinflammatory transcription factor NF-kappaB has been implicated in cell proliferation, apoptosis, and regulation of transepithelial sodium transport. The effect
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