H5752

17α-Hydroxyprogesterone

≥95%

• 동의어(들): 17α-Hydroxy-4-pregnene-3,20-dione, 4-Pregnen-17α-ol-3,20-dione
• 실험식(Hill 표기법): C₂₁H₃₀O₃
• CAS Number: 68-96-2
• Molecular Weight: 330.46
• Beilstein: 3218109
• EC Number: 200-699-4
• MDL number: MFCD00003659
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278469
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 무균: non-sterile
• 분석: ≥95%
• 형태: powder
• solubility: chloroform: 50 mg/mL, clear, colorless to light yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(C)=O
• InChI: 1S/C21H30O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h12,16-18,24H,4-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
• InChI key: DBPWSSGDRRHUNT-CEGNMAFCSA-N
• 유전자 정보: human ... PGR(5241) , SERPINA6(866) ; rat ... Ar(24208)

설명

일반 설명

17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase. 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid receptor.

애플리케이션

17α-Hydroxyprogesterone has been used:

• for titration against ovarian S9 protein in thin-layer chromatography
• as a substrate for hydroxysteroid dehydrogenase from B. megaterium cultures
• as a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)

생화학적/생리학적 작용

17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP. High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).

안전성 정보

• 픽토그램: GHS08,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H360FD,H411
• 예방조치 성명서: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Hazard Classifications: Aquatic Chronic 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges