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Merck
모든 사진(1)

문서

H7017

Sigma-Aldrich

Hemocyanin from Megathura crenulata (keyhole limpet)

동의어(들):

KLH, Keyhole limpet hemocyanin

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About This Item

CAS Number:
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.61

생물학적 소스

Megathura crenulata

Quality Level

형태

powder

포장

vial of KLH (KLH is present by weight at approximately 1 part KLH to 5 parts total solid.)

기술

ELISA: suitable

solubility

H2O: soluble

저장 온도

2-8°C

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일반 설명

Gastropod hemocyanins are massive glycoproteins (4 to 8 MDa) designed by an intricate arrangement of 10 subunits that are self-assembled into hollow cylinders 35 nm in diameter.
Hemocyanin is a high molecular weight copper containing glycoprotein. It reversibly binds oxygen and forms the extra-cellular respiratory protein of mollusks. Keyhole limpet hemocyanin (KLH) is filtered from the hemolymph of Megathura crenulata, also called the giant keyhole limpet. It is native to the southern California coast and Mexico.

애플리케이션

Keyhole limpet hemocyanin (KLH) is a strong and well known immune-stimulant in both experimental animals and humans. It has been used as a hapten carrier protein to enhance antigen-specific T cell priming and is known to stimulate a CD4+ T-cell response. Hemocyanins stimulate Th1 reactions without known side effects, which make them ideal for long-term continuous treatment of cancer.

물리적 형태

Lyophilized with stabilizing buffer

재구성

Reconstitute with deionized water to a KLH concentration of 10 mg/mL, to yield an opalescent solution in 31 mM sodium phosphate buffer, pH 7.4, containing 0.46 M NaCl, 2% PVP and 41 mM sucrose.
Reconstituted protein solution may be stored up to 2 months at −20 °C.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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