M1406

Anti-MAP2 Antibody

mouse monoclonal, AP-20

• 동의어(들): Anti-Microtubule Associated Protein 2
• MDL number: MFCD00164684
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 제품명: Anti-MAP2 (2a+2b) antibody, Mouse monoclonal, clone AP-20, ascites fluid
• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: AP-20, monoclonal
• 분자량: apparent mol wt 280 kDa
• 포함: 15 mM sodium azide
• 종 반응성: Xenopus, mouse, quail, human, bovine, rat, aquatic salamander
• 기술: immunocytochemistry: suitable; western blot: 1:500 using rat brain enriched microtubule protein preparation or rat cerebral cortex extract
• 동형: IgG1
• UniProt 수납 번호: P11137
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MAP2(4133) ; mouse ... Mtap2(17756) ; rat ... Map2(25595)

설명

일반 설명

Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. There are three forms of MAP2; two are similarly sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.
Monoclonal Anti-MAP2 (2a + 2b) (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

면역원

bovine MAP2

애플리케이션

Monoclonal Anti-MAP2 (2a+2b) antibody has been used in immunohistochemistry, immunocytochemistry and antibody characterization.

생화학적/생리학적 작용

Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology.

물리적 형태

The product is provided as ascites fluid with 15 mM sodium azide as a preservative.

저장 및 안정성

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1