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Merck
모든 사진(1)

주요 문서

M3696

Sigma-Aldrich

Anti-MAP2 Antibody

rabbit polyclonal

동의어(들):

Anti-Microtubule associated protein 2

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.41

제품명

Anti-MAP2 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

양식

buffered aqueous solution

분자량

antigen ~280 kDa
antigen ~72 kDa

종 반응성

rat, mouse, human

농도

~1 mg/mL

기술

flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... MAP2(4133)
mouse ... Mtap2(17756)
rat ... Map2(25595)

일반 설명

MAP2 is a microtubule-associated protein that regulates the structure and function of the cytoskeleton. The protein also modulates morphogenesis of neurons and cell proliferation. Interactions of MAP2 with F-actin have been implicated in neurite initiation and microtubular re-organization. Decreased levels of MAP2 have been associated with transmissible spongiform encephalopathies . Anti-MAP2 antibody is specific for MAP2 in human, mice and rats.
Microtubule associated protein 2 (MAP2) is a neuron specific protein, which is highly expressed in the central nervous system. It is the member of cytoskeletal proteins. The gene is located on human chromosome 2q34.

면역원

synthetic peptide corresponding to residues 2-15 of human MAP2.

애플리케이션

Anti-MAP2 antibody is suitable for use in immunohistochemistry (1:500 using Zamboni′s fixative-fixed, frozen mouse spinal cord and thalamus sections) , flow cytometry (1:200-1:500), immunoblotting (approx. 72 kDa and 280 kDa) and western blot (1:500-1:1,000).
Anti-MAP2 antibody produced in rabbit has been used in immunocytochemistry.

생화학적/생리학적 작용

Microtubule associated protein 2 (MAP2) plays a critical role in the formation of dendritic protrusions in astrocytes and oligodendrocytes. It maintains the homeostasis of microtubules. The protein plays an important role in neuronal plasticity.

물리적 형태

solution in phosphate buffered saline, containing 0.02% sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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문서 라이브러리 방문

Specific binding of dehydroepiandrosterone to the N terminus of the microtubule-associated protein MAP2
Laurine E, et al.
The Journal of Biological Chemistry, 278(32), 29979-29986 (2003)
Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells
Zhou Y, et al.
Neuro-Oncology, 17(12), 1578-1588 (2015)
Cory C Toth et al.
Molecular pain, 6, 16-16 (2010-03-20)
Despite the frequency of diabetes mellitus and its relationship to diabetic peripheral neuropathy (DPN) and neuropathic pain (NeP), our understanding of underlying mechanisms leading to chronic pain in diabetes remains poor. Recent evidence has demonstated a prominent role of microglial
Qinghai Liu et al.
PloS one, 11(4), e0153376-e0153376 (2016-04-14)
This study examines the effects of nano-size particulate matter (nPM) exposure in the setting of murine reperfused stroke. Particulate matter is a potent source of inflammation and oxidative stress. These processes are known to influence stroke progression through recruitment of
Leif Dehmelt et al.
Genome biology, 6(1), 204-204 (2005-01-12)
Microtubule-associated proteins (MAPs) of the MAP2/Tau family include the vertebrate proteins MAP2, MAP4, and Tau and homologs in other animals. All three vertebrate members of the family have alternative splice forms; all isoforms share a conserved carboxy-terminal domain containing microtubule-binding

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