T8578

Anti-β-Tubulin III Antibody

mouse monoclonal, 2G10

• 동의어(들): Anti-β-Tubulin Class III, Anti-Neuron-specifc class III β-tubulin, Anti-TUBB4, Anti-Tubb3, Anti-Tubulin β-4, Anti-Tubulin β-III, Anti-Tubulin, β−3
• MDL number: MFCD01323870
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• product name: Anti-β-Tubulin III (neuronal) antibody, Mouse monoclonal, ~1.0 mg/mL, clone 2G10, purified from hybridoma cell culture
• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: purified from hybridoma cell culture
• 항체 생산 유형: primary antibodies
• 클론: 2G10, monoclonal
• 형태: buffered aqueous solution
• 분자량: antigen ~50 kDa
• 종 반응성: human, mouse, rat
• 포장: antibody small pack of 25 μL
• 농도: ~1.0 mg/mL
• 기술: immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: 0.25-0.5 μg/mL using PC12 cell extract
• 동형: IgG2a
• UniProt 수납 번호: Q13509
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TUBB3(10381) ; mouse ... Tubb3(22152) ; rat ... Tubb3(246118)

설명

일반 설명

Tubulin β 3 class III (TUBB3) also known as β-Tubulin III, is encoded by the gene mapped to human chromosome 16q24.3. TUBB3 protein expression is restricted to neurons.

애플리케이션

Monoclonal Anti-β-Tubulin III (neuronal) antibody produced in mouse has been used in following studies:

• Immunofluorescence.
• Immunocytochemistry.

생화학적/생리학적 작용

Tubulin β 3 class III (TUBB3) plays a vital role in nervous system development and axon guidance. Mutation of the gene encoding protein leads to the ocular motility disorder, congenital fibrosis of the extraocular muscle type 3 (CFEOM3), and various neurological syndromes. Altered expression of the protein affects microtubule dynamics and microtubule-kinesin interactions. Increased expression of TUBB3 is observed in tumor tissues. Decreased expression of TUBB3 can be considered as an important marker for poor prognosis of cutaneous malignant melanoma. TUBB3 is implicated in the suppression of invasive growth of tumor tissue;therefore, it is considered to be a potential target for development of antitumor drugs.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)