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Merck
모든 사진(3)

주요 문서

N144

Sigma-Aldrich

Nitrendipine

>95%, powder

동의어(들):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester

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About This Item

실험식(Hill 표기법):
C18H20N2O6
CAS Number:
Molecular Weight:
360.36
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

분석

>95%

양식

powder

색상

yellow to green

solubility

methanol: 15 mg/mL
DMSO: 17.5 mg/mL
H2O: insoluble

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC

InChI

1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3

InChI key

PVHUJELLJLJGLN-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Ca2+ channel blocker; anti-hypertensive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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문서 라이브러리 방문

Xi Zhang et al.
International journal of pharmaceutics, 431(1-2), 45-52 (2012-05-01)
A novel active and multi-dose dry powder inhaler (DPI) was developed and evaluated to deliver a small quantity (100-500 μg) of pure drug without any excipient. This dry powder inhaler utilized two compressed air flows to dispense and deliver drug
Dengning Xia et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 46(5), 446-454 (2012-04-10)
The amorphous-to-crystalline transformation of nitrendipine was investigated using Raman spectroscopy and X-ray powder diffraction (XRPD). The nucleation and growth rate of crystalline nitrendipine in a medium containing poly (vinyl alcohol) (PVA) and polyethylene glycol (PEG 200) were quantitatively determined using
Peng Quan et al.
International journal of pharmaceutics, 430(1-2), 366-371 (2012-04-26)
In this study, chitosan, a cationic polymer with positive charge, was introduced to modify the nanocrystals of nitrendipine with negative charge. The nanocrystals were prepared via precipitation-high pressure homogenization method. Then the nanocrystals were dispersed into chitosan solution, and the
Dewei Shang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(30), 3459-3464 (2011-10-05)
A HPLC method with on-line solid phase extraction (SPE) and DAD detection was developed for the simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat (SHR) plasma. Plasma samples (100 μL) were injected directly onto a CAPCELL MF C(8)
Swathi Voruganti et al.
European journal of drug metabolism and pharmacokinetics, 37(2), 77-81 (2011-11-22)
Pomegranate juice (PJ) is known to be a potent inhibitor of human cytochrome enzymes. The purpose of this study was to investigate the effect of acute and chronic PJ on the pharmacokinetics of oral nitrendipine (10 mg/kg) in rabbits. Male New

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