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Merck
모든 사진(1)

주요 문서

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N7510

Sigma-Aldrich

Nicardipine hydrochloride

powder, ≥98%

동의어(들):

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methyl(phenylmethyl)amino]ethyl ester hydrochloride, YC-93

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C26H29N3O6 · HCl
CAS Number:
54527-84-3
Molecular Weight:
515.99
EC Number:
259-198-4
MDL number:
MFCD00057327
UNSPSC 코드:
12352200
PubChem Substance ID:
24277856
NACRES:
NA.77

Quality Level

100

분석

≥98%

형태

powder

색상

yellow

solubility

DMSO: ~1 mg/mL
0.1 M NaOH: insoluble
H2O: slightly soluble
methanol: soluble

주관자

EKR Therapeutics

저장 온도

2-8°C

SMILES string

Cl[H].COC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCCN(C)Cc3ccccc3

InChI

1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H

InChI key

AIKVCUNQWYTVTO-UHFFFAOYSA-N

유전자 정보

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Blocks L-type voltage-dependent calcium channels; antihypertensive.

특징 및 장점

This compound was developed by EKR Therapeutics. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Skull and crossbones
GHS06

신호어

Danger

유해 및 위험 성명서

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

시험 성적서(COA)

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문서 라이브러리 방문

GoEun Han et al.
Frontiers in neuroscience, 16, 969712-969712 (2022-11-08)
Non-rapid eye movement (NREM) sleep is tightly homeostatically regulated and essential for survival. In the electroencephalogram (EEG), oscillations in the delta (0.5-4 Hz) range are prominent during NREM sleep. These delta oscillations are, to date, the best indicator for homeostatic
E M Fitzgerald
The Journal of physiology, 527 Pt 3, 433-444 (2000-09-16)
The small G-protein Ras, a critical component in the signalling pathways regulating cell growth, is involved in the tonic upregulation of voltage-dependent calcium channels (VDCCs) in rat sensory neurones. To investigate which downstream effector(s) of Ras is involved in this
T J Hibberd et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 29(10), 1-12 (2017-04-19)
Relatively little is known about the electrical rhythmicity of the whole colon, where long neural pathways are preserved. Smooth muscle electrical activity was recorded extracellularly from the serosa of isolated flat-sheet preparations consisting of the whole mouse colon (n=31). Two
S Thellung et al.
Neurobiology of disease, 7(4), 299-309 (2000-08-31)
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrP(Sc). A synthetic peptide homologous to residues 106-126 of PrP (PrP106-126) was reported to maintain the neurodegenerative characteristics of
Prasanna P K M Gamage et al.
Journal of cellular and molecular medicine, 22(10), 5160-5164 (2018-07-27)
Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal impaction and incontinence. Interstitial cells of cajal (ICC) play an important role in regulation of intestinal smooth muscle contraction. However
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