P1784

Pentoxifylline

solid

• 동의어(들): 3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
• 실험식(Hill 표기법): C₁₃H₁₈N₄O₃
• CAS Number: 6493-05-6
• Molecular Weight: 278.31
• EC Number: 229-374-5
• MDL number: MFCD00063379
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24278190
• NACRES: NA.77

속성

• 형태: solid
• Quality Level: 100
• 색상: white
• solubility: H₂O: ≥43 mg/mL, colorless to almost colorless
• 주관자: Sanofi Aventis
• SMILES string: CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
• InChI: 1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
• InChI key: MQGNNJQTNFHNHK-UHFFFAOYSA-N
• 유전자 정보: human ... ADORA2B(136) , LITAF(9516) , PDE4B(5142) , TNF(7124) ; rat ... Tnf(24835)

설명

애플리케이션

Pentoxifylline has been used:

• used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
• to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
• to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

생화학적/생리학적 작용

Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.

Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H362
• 예방조치 성명서: P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Lact.
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves