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Merck
모든 사진(1)

문서

P0510000

Pentoxifylline

European Pharmacopoeia (EP) Reference Standard

동의어(들):

3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental

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About This Item

실험식(Hill 표기법):
C13H18N4O3
CAS Number:
Molecular Weight:
278.31
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

pharmaceutical primary standard

API family

pentoxifylline

제조업체/상표

EDQM

응용 분야

pharmaceutical (small molecule)

형식

neat

SMILES string

CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C

InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3

InChI key

MQGNNJQTNFHNHK-UHFFFAOYSA-N

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일반 설명

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

애플리케이션

Pentoxifylline EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

생화학적/생리학적 작용

Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

포장

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

기타 정보

Sales restrictions may apply.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Lact.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Umair Sohail et al.
Clinics in liver disease, 16(4), 717-736 (2012-10-30)
Alcoholic hepatitis is a form of severe, cholestatic liver disease that results from consumption of large amount of alcohol during a sustained period of time in a subset of alcoholics. Symptoms could be mild and nonspecific to more severe. The diagnosis
John M Akudugu et al.
International journal of radiation biology, 89(6), 462-470 (2013-02-01)
The mode by which the xanthine derivative, pentoxifylline, induces a radiosensitizing effect in cell cultures is a key and controversial radiobiological issue and requires further elucidation. Six human glioblastoma cell lines were tested for the effect of pentoxifylline treatment at
Saad Hamama et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 105(3), 305-312 (2012-10-02)
Radiation-induced fibrosis is a serious late complication of radiotherapy. Pentoxifylline-vitamin E has proven effective and safe in clinical trials in the treatment of fibrosis, while the molecular mechanism of its activity is yet unexplored. Ten patients suffering from radiation-induced enteropathy
Cheng-Chung Fang et al.
PloS one, 7(9), e44765-e44765 (2012-10-03)
Excessive fibrin deposition in the peritoneum is thought to be involved in the development of encapsulating peritoneal sclerosis (EPS), an important cause of morbidity and mortality in peritoneal dialysis patients. We investigated fibrin-induced epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells
Alejandro Bravo-Cuellar et al.
Journal of biomedical science, 20, 13-13 (2013-03-01)
In Oncology, the resistance of the cancerous cells to chemotherapy continues to be the principal limitation. The nuclear factor-kappa B (NF-κB) transcription factor plays an important role in tumor escape and resistance to chemotherapy and this factor regulates several pathways

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