P2200

Protein C from human plasma

Activated, lyophilized powder, ≥90% (SDS-PAGE)

• 동의어(들): Activated Protein C
• CAS Number: 42617-41-4
• 효소 위원회 번호: 3.4.21.69 (BRENDA, IUBMB)
• MDL number: MFCD00165567
• UNSPSC 코드: 12352202
• NACRES: NA.61

속성

• 생물학적 소스: human plasma
• Quality Level: 200
• 분석: ≥90% (SDS-PAGE)
• 형태: lyophilized powder
• 분자량: heavy chain 41 kDa; light chain 21 kDa
• 기술: inhibition assay: suitable
• solubility: H₂O: 1 mg/mL
• UniProt 수납 번호: P04070
• 저장 온도: −20°C
• 유전자 정보: human ... PROC(5624)

설명

일반 설명

Protein C from human plasma is encoded by the gene PROC. In human chromosome, the gene is localised on chromosome 2q14. Activated protein C (APC) cleaves protease activated receptor 1 (PAR1) resulting in cytoprotective and anti-inflammatory effects. Clinical trials with APC implicates its use in treating severe early onset preeclampsia in pregnant women and prolongs pregnancy and helps in perinatal outcomes.

애플리케이션

Protein C from human plasma has been used for pre-treatment of endothelial cells prior to antibody-inhibition assay. It has also been used in activated protein C (APC) assay to determine its inhibitory effect on copper.

생화학적/생리학적 작용

In addition, activated protein C has been shown to inhibit TNF-α induced expression of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells.

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa.

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels.

물리적 형태

Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable