추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
DMSO: ≥20 mg/mL
ethanol: 24 mg/mL
H2O: insoluble
저장 온도
room temp
SMILES string
OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4
InChI
1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
InChI key
LLBLNMUONVVVPG-UHFFFAOYSA-N
유전자 정보
human ... DRD2(1813) , DRD3(1814) , DRD4(1815)
애플리케이션
L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells. It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.
생화학적/생리학적 작용
L-741,626 is a selective dopamine (D2) receptor antagonist.
특징 및 장점
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Florence Loiseau et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(1), 23-33 (2008-09-17)
Though D(3) receptor antagonists can enhance cognitive function, their sites of action remain unexplored. This issue was addressed employing a model of social recognition in rats, and the actions of D(3) antagonists were compared to D(1) agonists that likewise possess
B J Bowery et al.
British journal of pharmacology, 119(7), 1491-1497 (1996-12-01)
1. The ability of PD 128907 to activate dopamine receptors in the ventral tegmental area, substantia nigra pars compacta, and striatum was investigated by use of in vitro electrophysiological recording and fast cyclic voltammetry. The affinity of a novel D2
Masaki Nakano et al.
General and comparative endocrinology, 168(2), 287-292 (2010-06-18)
Dopamine receptors in mammals are known to consist of two D1-like receptors (D1 and D5) and three D2-like receptors (D2, D3 and D4). The aim of this study was to determine the dopamine receptor subtype that mediates the inhibitory action
Wen-Ling Dai et al.
Scientific reports, 6, 38746-38746 (2016-12-23)
Tolerance induced by morphine remains a major unresolved problem and significantly limits its clinical use. Recent evidences have indicated that dopamine D2 receptor (D2DR) is likely to be involved in morphine-induced antinociceptive tolerance. However, its exact effect and molecular mechanism
Kotaro Hattori et al.
The Journal of biological chemistry, 281(11), 7129-7135 (2006-01-13)
Fyn-mediated tyrosine phosphorylation of N-methyl-D-aspartate (NMDA) receptor subunits has been implicated in various brain functions, including ethanol tolerance, learning, and seizure susceptibility. In this study, we explored the role of Fyn in haloperidol-induced catalepsy, an animal model of the extrapyramidal
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