P3076

Platelet-Derived Growth Factor-AA human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 동의어(들): PDGF−AA
• MDL number: MFCD00081862
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• product name: Platelet-Derived Growth Factor-AA human, PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 100
• 재조합: expressed in E. coli
• 분석: ≥98% (SDS-PAGE and HPLC)
• 형태: lyophilized powder
• 효능: 1.0-3.0 ng/mL ED₅₀
• 품질: endotoxin tested
• 분자량: 28.5 kDa (containing 250 amino acid residues)
• 포장: pkg of 10 μg; pkg of 50 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 기술: cell culture | mammalian: suitable
• 불순물: <1 EU/μg
• UniProt 수납 번호: P04085
• 저장 온도: −20°C
• 유전자 정보: human ... PDGFRA(5154)

설명

일반 설명

Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.

생화학적/생리학적 작용

Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.

기타 정보

Homodimer of the A chain of human PDGF.

물리적 형태

Sterile-filtered through a 0.2 μm filter. Lyophilized with 10 mM acetic acid.

분석 메모

The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable