P6503

Pilocarpine hydrochloride

≥99% (titration), powder, muscarinic acetylcholine receptor agonist

• 동의어(들): (3S,4R)-4,5-Dihydro-3-ethyl-4-(1-methyl-1H-imidazol-5-ylmethyl)-2(3H)-furanone hydrochloride
• 실험식(Hill 표기법): C₁₁H₁₆N₂O₂ · HCl
• CAS Number: 54-71-7
• Molecular Weight: 244.72
• Beilstein: 4034491
• EC Number: 200-212-5
• MDL number: MFCD00012722
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277862
• NACRES: NA.77

속성

• 제품명: Pilocarpine hydrochloride, ≥99% (titration), powder
• Quality Level: 100
• 분석: ≥99% (titration)
• 양식: powder
• 기술: HPLC: suitable; gas chromatography (GC): suitable
• 색상: white
• mp: 202-205 °C (lit.)
• solubility: H₂O: 100 mg/mL
• 응용 분야: forensics and toxicology; veterinary
• 관련 질환(들): epilepsy
• SMILES string: Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
• InChI: 1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
• InChI key: RNAICSBVACLLGM-GNAZCLTHSA-N
• 유전자 정보: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

설명

애플리케이션

Pilocarpine hydrochloride has been used to stimulate salivary secretions in mice. It has also been used to induce status epilepticus(SE) in rat.

생화학적/생리학적 작용

Pilocarpine is alkaloid isolated from the shrub Pilocarpus species. It comprises imidazole ring and γ- lactone rings in its structure. It has cholinergic potential and it stimulates the parasympathetic system. Pilocarpine is also effective for treating glaucoma. It stimulates ciliary muscle contraction by binding to muscarinic M3 receptors. It is effective in treating corneal dryness in Sjogren′s syndrome. It is a secretagogue, which improves salivary secretions in Xerostomia or a dry mouth condition in Sjogren′s syndrome patients and in radiotherapy patients with head and neck carcinoma.

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

특징 및 장점

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Hygroscopic, light sensitive

기타 정보

Shelf life of the powder is at least five years.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H330
• 예방조치 성명서: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3