S8502

(−)-Scopolamine methyl bromide

≥98% (HPLC), powder

• 동의어(들): Hyoscine methyl bromide, Methscopolamine bromide
• 실험식(Hill 표기법): C₁₈H₂₄NO₄ · Br
• CAS Number: 155-41-9
• Molecular Weight: 398.29
• EC Number: 205-844-5
• MDL number: MFCD00078560
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24278714
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (HPLC)
• 형태: powder
• 광학 활성: [α]25/D −25°, c = 5 in H₂O(lit.)
• 색상: white
• solubility: H₂O: 50 mg/mL
• SMILES string: [Br-].[H][C@]12C[C@@H](C[C@]([H])([C@@]3([H])O[C@@]13[H])[N+]2(C)C)OC(=O)[C@H](CO)c4ccccc4
• InChI: 1S/C18H24NO4.BrH/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11;/h3-7,12-17,20H,8-10H2,1-2H3;1H/q+1;/p-1/t12-,13-,14-,15+,16-,17+;/m1./s1
• InChI key: CXYRUNPLKGGUJF-RAFJPFSSSA-M
• 유전자 정보: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

설명

애플리케이션

(−)-Scopolamine methyl bromide was administered to rats to inhibit the peripheral cholinergic effects induced by pilocarpine.^10,11

생화학적/생리학적 작용

Competitive muscarinic acetylcholine receptor antagonist.

Scopolamine is an anti-muscarinic and cholinolytic alkaloid that inhibits parasympathetic-cholinergic system.⁷ The central effects include hallucinations, disorientation, restlessness and euphoria.⁸ Scopolamine disturb the stimulus detection performance in rats by interfering with the reticular cholinergic pathways.⁹

주의사항

Shelf-life of the powder is at least five years when stored at room temperature.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H312 + H332,H400
• 예방조치 성명서: P261 - P271 - P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves