P8232

Anti-P2X₇ Purinergic Receptor antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• 동의어(들): Anti-P2X₇ Antibody, P2X₇ Receptor Detection, Rabbit Anti-P2X₇
• MDL number: MFCD02097118
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: lyophilized powder
• 종 반응성: human, mouse, rat
• 기술: immunohistochemistry: suitable; western blot: 1:200-1:1,000
• UniProt 수납 번호: Q99572
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... P2RX7(5027) ; mouse ... P2rx7(18439) ; rat ... P2rx7(29665)

설명

일반 설명

Purinergic receptor P2X₇ is an ATP-gated cation channel. It is expressed in retinal pigmented epithelium and neural retina. The gene encoding this protein is localized on human chromosome 12.

면역원

Peptide (C)KIRKEFPKTQGQYSGFKYPY, corresponding to amino acid residues 576-595 of rat P2X7 Receptor (Accession Q64663). Intracellular, C-terminus.

애플리케이션

Anti-P2X7 Purinergic Receptor antibody produced in rabbit has been used in

• immunoprecipitation
• immunofluorescence and confocal microscopy
• western blotting

생화학적/생리학적 작용

Purinergic receptor P2X₇ has a role in immunological processes. It has a role during oxidative stress under pathological conditions. The channel is permeable to Na⁺, Ca²⁺ and K⁺. Prolonged activation of the channel under some pathological conditions leads to the passage of large molecules and ultimately cell death. P2X7 may be involved in the release of interleukin-1β (IL-1β) and indirectly initiate an inflammatory cascade.

물리적 형태

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

저장 및 안정성

Prior to reconstitution, store at –20°C. After reconstitution, the stock antibody solution may be stored at 2–8°C for up to two weeks. For extended storage, freeze at -20°C, or below, in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. Centrifuge all antibody preparations before use (10,000 x g 5 min). Working dilution samples should be discarded if not used within 12 hours.

기타 정보

In order to obtain the best results using various techniques and preparations, we recommend determining the optimal working dilutions by titration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable