S0569

SB 239063

>98% (HPLC)

• 동의어(들): trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole
• 실험식(Hill 표기법): C₂₀H₂₁N₄O₂F
• CAS Number: 193551-21-2
• Molecular Weight: 368.40
• MDL number: MFCD03792786
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824431
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >98% (HPLC)
• 양식: powder
• 색상: white
• mp: 206-207.2 °C
• solubility: DMSO: 11 mg/mL; H₂O: insoluble
• 주관자: GlaxoSmithKline
• 저장 온도: 2-8°C
• SMILES string: COc1nccc(n1)-c2c(ncn2[C@@H]3CC[C@@H](O)CC3)-c4ccc(F)cc4
• InChI: 1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16-
• InChI key: ZQUSFAUAYSEREK-WKILWMFISA-N

설명

일반 설명

SB 239063 helps to decrease neutrophilia, inflammatory cytokines, matrix metallopeptidase 9 (MMP-9) and fibrosis in the lung.

애플리케이션

SB 239063 has been used to determine the roles of c-Jun N-terminal kinase (JNK), p38 MAP kinase, and extracellular signal regulated protein kinase (ERK)/p42/p44 mitogen activated protein kinase (MAPK) on the viability and apoptosis of cardiomyocytes under glutathione S-transferase (GST) inhibition. It has also been used in neuron-microglia conditioned media (CM) experiments and pharmacokinetics.

생화학적/생리학적 작용

Potent p38 MAP kinase inhibitor. Selective for α and β. No activity against γ and δ isoforms.

특징 및 장점

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

법적 정보

Sold for research purposes under agreement from Glaxo­Smith­Kline

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)