P215

PD 98,059

solid

• 동의어(들): 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
• 실험식(Hill 표기법): C₁₆H₁₃NO₃
• CAS Number: 167869-21-8
• Molecular Weight: 267.28
• MDL number: MFCD00671789
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278666
• NACRES: NA.77

속성

• 형태: solid
• Quality Level: 100
• 색상: yellow
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
• InChI: 1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
• InChI key: QFWCYNPOPKQOKV-UHFFFAOYSA-N
• 유전자 정보: human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)

설명

애플리케이션

PD 98,059 has been used:

• in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
• in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
• in culture medium for cell migration assay

생화학적/생리학적 작용

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

특징 및 장점

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

법적 정보

Sold with permission of Warner Lambert Company.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves