추천 제품
생물학적 소스
human serum
Quality Level
분석
≥95% (SDS-PAGE)
형태
buffered aqueous glycerol solution
기술
cell culture | mammalian: suitable
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
유전자 정보
human ... SHBG(6462)
일반 설명
Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.
애플리케이션
Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.
생화학적/생리학적 작용
Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.
물리적 형태
Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China
A STROBE-compliant article
A STROBE-compliant article
Yuan-rong Cui
Medicine (2017)
Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.
Fortunati N
Molecular and Cellular Endocrinology (2010)
Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
Konkle ATM and McCarthy MM
Endocrinology, 152(1), 223-235 (2011)
The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
Gregoraszczuk EL
Endocrine regulations (2011)
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