S3442

SB 216763

>98% (HPLC)

• 동의어(들): 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• 실험식(Hill 표기법): C₁₉H₁₂N₂O₂Cl₂
• CAS Number: 280744-09-4
• Molecular Weight: 371.22
• MDL number: MFCD09753369
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278616
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: >98% (HPLC)
• 색상: orange
• solubility: DMSO: soluble 20 mg/mL; H₂O: insoluble
• 주관자: GlaxoSmithKline
• 저장 온도: −20°C
• SMILES string: Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14
• InChI: 1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
• InChI key: JCSGFHVFHSKIJH-UHFFFAOYSA-N
• 유전자 정보: human ... GSK3A(2931) , GSK3B(2932)

설명

애플리케이션

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

생화학적/생리학적 작용

Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

법적 정보

Sold for research purposes under agreement from Glaxo­Smith­Kline

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves