추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
human
농도
~1.0 mg/mL
기술
indirect immunofluorescence: 1-2 μg/mL using human HeLa cells
western blot: 1-2 μg/mL using whole extracts of human platelets
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... RAB32(10981)
관련 카테고리
일반 설명
The gene RAB32 (Ras-related protein) is mapped to human chromosome 6q24.3. It is a Rab GTPase which is present in the mitochondria. The protein also has a transient phagosomal localization and is also present at the melanosome membrane.
애플리케이션
Anti-Rab32 antibody produced in rabbit has been used for western blotting and immunofluorescence.
생화학적/생리학적 작용
RAB32 (Ras-related protein) controls intracellular lipid accumulation in hepatocytes. Absence of it promotes the expression of ATGL (adipose triglyceride lipase) and thereby causes lipolysis. RAB32 is involved in hepatic steatosis. In melanogenesis, it is involved in the transport of important enzymes, such as tyrosinase and Tyrp1 (tyrosinase related protein 1). RAB32 also interacts with and is involved in localization of leucine-rich repeat kinase 2 (LRRK2), a protein associated with Parkinson′s disease. RAB32 is hypermethylated in microsatellite-unstable colon, gastric and endometrial adenocarcinomas.
Rab32 facilitates mitochondrial anchoring of protein kinaseA (PKA) and mitochondrial dynamics. Rab32 was also found to be required for the formation of autophagic vacuoles.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages.
Hoffmann C, et al.
Cellular Microbiology, 16, 1034-1052 (2014)
Waschbusch D, et al.
<BIG>Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking</BIG>
PLoS ONE, 14, e0208889-e0208889 (2019)
Dieter Waschbüsch et al.
PloS one, 14(1), e0208889-e0208889 (2019-01-15)
The Rab family of small GTPases regulate various aspects of cellular dynamics in eukaryotic cells. Membrane trafficking has emerged as central to the functions of leucine-rich repeat kinase 2 (LRRK2), which is associated with inherited and sporadic forms of Parkinson's
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J Cell Biol 158: 659-668
Alto NM, et al.
The Journal of cell biology, 158(4), 659-668 (2002)
Kai Yasukawa et al.
The Journal of biological chemistry, 295(2), 444-457 (2019-11-27)
MicroRNAs (miRNAs) are small noncoding RNAs that suppress the expression of multiple genes and are involved in numerous biologic functions and disorders, including human diseases. Here, we report that two miRNAs, miR-302b and miR-372, target mitochondrial-mediated antiviral innate immunity by
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