SBR00041

Cefiderocol

• 동의어(들): S-649266
• 실험식(Hill 표기법): C₃₀H₃₄ClN₇O₁₀S₂
• CAS Number: 1225208-94-5
• Molecular Weight: 752.21
• MDL number: MFCD30533432
• UNSPSC 코드: 12352111
• NACRES: NA.76

속성

• 분석: ≥95% (HPLC)
• Quality Level: 100
• 형태: solid
• 반응 적합성: reagent type: chelator
• 항생제 활성 스펙트럼: Gram-negative bacteria
• 동작 모드: protein synthesis | inhibits
• 저장 온도: −20°C
• SMILES string: NC1=NC(/C(C(N[C@@H]2C(N3[C@@H]2SCC(C[N+]4(CCCC4)CCNC(C5=CC=C(O)C(O)=C5Cl)=O)=C3C([O-])=O)=O)=O)=N/OC(C(O)=O)(C)C)=CS1
• InChI: 1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
• InChI key: DBPPRLRVDVJOCL-FQRUVTKNSA-N

설명

일반 설명

Cefiderocol has been shown to be effective in preventing the emergence of resistant mutants but is not active against methicillin-resistant Staphylococcus aureus (MRSA) or colistin-resistant bacteria. This versatile compound finds applications in cell biology and biochemical research.

Cefiderocol is a novel injectable siderophore cephalosporin, which was formerly known as S-649266. It has a catechol-type siderophore and cephalosporin core and side chains. Cefiderocol has structural similarity with both ceftazidime and cefepime, besides the chlorocatechol group on the end of the C-3 chain.

애플리케이션

Cefiderocol has been used:

• study bacterial infections and tracking their uptake in vivo
• the study of the activity of Cefiderocol against gram-negative bacteria

생화학적/생리학적 작용

Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.

Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.

특징 및 장점

• High-quality antibiotic suitable for multiple research applications
• Ideal for Cell Biology and Biochemical research

기타 정보

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면책조항

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable