I0160

Imipenem monohydrate

≥98% (HPLC)

• 동의어(들): (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate
• 실험식(Hill 표기법): C₁₂H₁₇N₃O₄S · H₂O
• CAS Number: 74431-23-5
• Molecular Weight: 317.36
• EC Number: 264-734-5
• MDL number: MFCD09753321
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329815301
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 광학 활성: [α]/D +73 to +84°, c = 0.5 in water
• 색상: white to beige
• solubility: H₂O: >5 mg/mL
• 항생제 활성 스펙트럼: mycobacteria
• 동작 모드: cell wall synthesis | interferes
• 주관자: Merck & Co., Inc., Kenilworth, NJ, U.S.
• 저장 온도: −20°C
• SMILES string: O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O
• InChI: 1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1
• InChI key: GSOSVVULSKVSLQ-JJVRHELESA-N

설명

일반 설명

Chemical structure: ß-lactam

애플리케이션

Imipenem monohydrate has been used to determine the resistance profiles of Pseudomonas aeruginosa isolates. It has also been used in susceptibility testing against Acinetobacter baumannii.

생화학적/생리학적 작용

Imipenem is found effective against gram positive and negative aerobes and anaerobes. Imipenem is often combined with cilastatin, to inhibit its metabolism in kidney.

Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

특징 및 장점

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)