모든 사진(1)
About This Item
실험식(Hill 표기법):
C30H47NO4S
CAS Number:
Molecular Weight:
517.76
MDL number:
UNSPSC 코드:
51284706
NACRES:
NA.76
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
항생제 활성 스펙트럼
Gram-positive bacteria
동작 모드
protein synthesis | interferes
저장 온도
−20°C
SMILES string
S(C4C[C@@H]5N([C@@H](CC5)C4)C)CC(=O)O[C@H]1[C@]2([C@H]3[C@@]([C@H]([C@@H]([C@](C1)(C)C=C)O)C)(CC[C@H]2C)CCC3=O)C
InChI
1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
InChI key
STZYTFJPGGDRJD-FJJJPKKESA-N
일반 설명
Retapamulin (RET) is a semi-synthetic antibiotic ointment, and pleuromutilin derivative compound. The primary structural difference between pleuromutilin and retapamulin is in the C-14 side chain.
생화학적/생리학적 작용
Retapamulin is a potent antibacterial agent against Gram-positive bacteria, especially against Staphylococcus aureus and S. pyogenes. It displays synergistic effects against Enterococcus faecalis in combination with streptogramin (MLS). RET initiates ribosomal arrests at the start codon and enables genes to use alternative translational sites in E. coli.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
In vitro synergistic effect of retapamulin with erythromycin and quinupristin against Enterococcus faecalis
Park B, et al
The Journal of Antibiotics, 73, 630-635 (2020)
Retapamulin-Assisted Ribosome Profiling Reveals the Alternative Bacterial Proteome
Meydan S, et al
Molecular Cell, 74, 481-493 (2019)
Retapamulin: Current Status and Future Perspectives
Goudarzi M, et al
Archives of Clinical Infectious Diseases, 16, 4-4 (2021)
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