SML0248
Zolmitriptan
≥98% (HPLC)
동의어(들):
(4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone, (S)-4-((3-(2-(Dimethylamino)ethyl)indol-5-yl)methyl)-2-oxazolidinone, 311C90
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C16H21N3O2
CAS Number:
Molecular Weight:
287.36
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
![Octahydrocyclopenta[c]pyrrole AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/385/398/e59a3455-5fde-4e4a-a173-43297760be22/640/e59a3455-5fde-4e4a-a173-43297760be22.png)
Quality Level
분석
≥98% (HPLC)
양식
powder
광학 활성
[α]/D -3 to -8°, c = 1 in methanol
색상
white to beige
solubility
DMSO: ≥5 mg/mL
저장 온도
2-8°C
SMILES string
CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12
InChI
1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1
InChI key
ULSDMUVEXKOYBU-ZDUSSCGKSA-N
유전자 정보
human ... HTR1B(3351) , HTR1D(3352)
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애플리케이션
Zolmitriptan has been used as a 5-hydroxytryptamine receptor 1B (5-HT1B/D) activator to treat grafts to study its effects on the morphology of the ectopic eye.
Zolmitriptan has been used to induce hyper-innervation of transplants.
생화학적/생리학적 작용
Zolmitriptan is a potent, selective. centrally and peripherally acting 5HT1B/1D receptor agonist.
Zolmitriptan is a selective serotonin receptor agonist of the 5HT1B and 5HT1D subtypes, both centrally and peripherally. It has been used clinically for the acute treatment of migraine attacks with or without aura and cluster headaches.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Gianni Allais et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 32 Suppl 1, S99-104 (2011-05-06)
Menstrually related migraine (MRM) is a particularly difficult-to-treat pain condition, associated with substantial disability. Aim of this study was to compare the efficacy and safety of frovatriptan and zolmitriptan in the treatment of MRM attacks, analyzing data from a multicenter
Marek Gawel et al.
Expert opinion on pharmacotherapy, 6(6), 1019-1024 (2005-06-15)
Intranasal zolmitriptan has recently been launched in the US and Canada and is a novel formulation of the antimigraine drug zolmitriptan. This drug has been used extensively in its oral formulation. The intranasal formulation offers a more rapid onset of
Luana Lionetto et al.
Expert opinion on drug metabolism & toxicology, 8(8), 1043-1050 (2012-07-06)
Migraine is a multifactorial neurovascular disorder characterized by recurrent episodes of disabling pain attacks, accompanied with gastrointestinal, neurological systems dysfunction. The pharmacologic treatment of migraine is classically divided in the management of the acute attack and preventive strategies. Acute treatments
Vincenzo Tullo et al.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 33 Suppl 1, S61-S64 (2012-06-01)
Migraine with aura affects ~20-30 % of migraineurs and it is much less common than migraine without aura. The aim of this study was to compare the efficacy of frovatriptan 2.5 mg and zolmitriptan 2.5 mg in the treatment of
Tony W Ho et al.
Headache, 51(1), 64-72 (2010-11-09)
To evaluate whether the same or different patients respond to triptans and telcagepant. Telcagepant is an oral calcitonin gene-related peptide receptor antagonist with acute antimigraine efficacy comparable to oral triptans. It is currently unknown whether migraine patients who cannot be
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