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Merck
모든 사진(1)

주요 문서

SML0593

Sigma-Aldrich

CGP52432

≥98% (HPLC)

동의어(들):

[3-[[(3,4-Dichlorophenyl)methyl]amino]propyl](diethoxymethyl)-phosphinic acid

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C15H24Cl2NO4P
CAS Number:
139667-74-6
Molecular Weight:
384.24
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

desiccated

색상

white to beige

solubility

H2O: 1 mg/mL, clear (warmed)

저장 온도

2-8°C

SMILES string

[P](=O)(O)(C(OCC)OCC)CCCNCc1cc(c(cc1)Cl)Cl

InChI

1S/C15H24Cl2NO4P/c1-3-21-15(22-4-2)23(19,20)9-5-8-18-11-12-6-7-13(16)14(17)10-12/h6-7,10,15,18H,3-5,8-9,11H2,1-2H3,(H,19,20)

InChI key

GJZVQXWEIYRHBE-UHFFFAOYSA-N

애플리케이션

CGP52432 has been used as a γ-aminobutyric acid B (GABAB) antagonist:
  • to study its effects on the simulation of the onset of status epilepticus (SE) in mice
  • for voltage-clamp recording in mice neurons
  • to study its effects on the GABAB receptor-mediated neurotransmission in guinea pig hippocampus

생화학적/생리학적 작용

CGP52432 is a very potent antagonist of GABAB receptors. (IC50 = 85 nM).
CGP52432 participates in inhibiting the glycine overflow in the hippocampus.

특징 및 장점

This compound is featured on the GABAB Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

기타 정보

Do not freeze.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000178622
126M4719V
013M4737V

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문서 라이브러리 방문

Cristina Romei et al.
Pharmacological research, 61(6), 547-552 (2010-02-09)
GABA(B) receptors mediate inhibition of neurotransmitter exocytosis from nerve endings. Unexpectedly, the well known GABA(B) receptor antagonist CGP35348 and, in part, the compound CGP52432, are now found to inhibit on their own the K(+)-evoked exocytosis of glycine when added at
Kazuo Kitamura et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10847-10858 (2011-07-29)
Cerebellar Purkinje cells have one of the most elaborate dendritic trees in the mammalian CNS, receiving excitatory synaptic input from a single climbing fiber (CF) and from ∼200,000 parallel fibers. The dendritic Ca(2+) signals triggered by activation of these inputs
Chunguang Zhang et al.
Endocrinology, 150(5), 2388-2394 (2009-01-24)
Gamma-aminobutyric acid (GABA) is one of the most important neurotransmitters that regulate the excitability of GnRH neurons. Numerous studies have shown that GABA activates Cl(-) currents in GnRH neurons, and these effects are antagonized by GABA(A) receptor antagonists. The GABA(B)
A E Matukhno et al.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 62(3), 372-382 (2012-08-16)
By means of local microapplication of GABA, picrotoxin and CGP 52432, different roles of GABAA and GABAB receptors in the geneses of primary and secondary components of evoked potentials in the somatosensory barrel cortex of rats were shown. The authors
Shuhei Kobuchi et al.
European journal of pharmacology, 623(1-3), 113-118 (2009-09-22)
Enhanced renal sympathetic nerve activity during ischemic period and the renal venous norepinephrine overflow after reperfusion play important roles in the development of ischemic acute kidney injury. We investigated the effect of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter mainly in
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