추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 10 mg/mL, clear
저장 온도
2-8°C
SMILES string
OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3
InChI
1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H
InChI key
DHSASSJDMAHICE-UHFFFAOYSA-N
생화학적/생리학적 작용
Potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties
Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.
Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. Sparstolonin B inhibits LPS induced inflammation in 3T3- L1 adipocytes, and reduces the body weight of rats fed with high fat diet. Sparstolonin B mitigates inflammation in nonalcoholic steatohepatitis (NASH) in mice model.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Xin Deng et al.
Virology journal, 12, 108-108 (2015-07-25)
The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection. We found that SsnB treatment blocked
Ming Wang et al.
European journal of pharmacology, 769, 79-85 (2015-11-03)
Sparstolonin B (SsnB), an isocoumarin compound isolated from the tubers of both Sparganium stoloniferum and Scirpus yagara, has been reported to have anti-inflammatory effects. However, whether SsnB has anti-inflammatory effects on LPS-stimulated 3T3-L1 adipocytes remains unclear. In this study, we
Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation
Liu Q, et al.
Exp. Biol. Med, 239(3), 376-384 (2014)
Diptadip Dattaroy et al.
American journal of physiology. Gastrointestinal and liver physiology, 310(7), G510-G525 (2016-01-01)
Although significant research data exist on the pathophysiology of nonalcoholic steatohepatitis (NASH), finding an efficient treatment regimen for it remains elusive. The present study used sparstolonin B (SsnB), a novel TLR4 antagonist derived from the Chinese herb Sparganium stoloniferum, as
Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties.
Liang Q, et al.
The Journal of Biological Chemistry, 286(30), 26470-26479 (2011)
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