SML3306

BAY-390

≥98% (HPLC)

• 동의어(들): (1R,2R)-2-(4-Fluorophenylamino)-1-(trifluoromethyl)cyclohexanol, BAY 390, BAY390
• 실험식(Hill 표기법): C₁₃H₁₅F₄NO
• CAS Number: 2741956-55-6
• Molecular Weight: 277.26
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: oil
• 색상: yellow to orange
• 저장 온도: 2-8°C
• SMILES string: FC1=CC=C(C=C1)N[C@H]2[C@@](C(F)(F)F)(CCCC2)O
• InChI key: IESAJAZKMLPVIB-VXGBXAGGSA-N

설명

생화학적/생리학적 작용

BAY-390 is an orally active, potent and selective TRPA1 inhibitor (cellular Ca++ influx IC50 in nM by FLIPR = 16/hu, 19/monkey, 63/rat, 68/guinea pig, 73/mu, 81/dog; IC50 = 5.6 µM/hTRPC5, >25 µM/human TRPV1/4, TRPC3/6, KCNK9 (TASK-3), CACNA1H (Cav3.2)) that shows in vivo efficacy in animal models of inflammatory pain (30 or 90 mg/kg mice, p.o.) and neurogenic pain (30 or 90 mg/kg rats, b.i.d. p.o.).

Oally active, potent and selective TRPA1 inhibitor with in vivo efficacy in inflammatory and neurogenic pain models.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable