SML3433

NVP-TNKS656

≥98% (HPLC)

• 동의어(들): ; N-Cyclopropylmethyl-2-[4-(4-methoxybenzoyl)piperidin-1-yl]-N-[(4-oxo-4,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide, N-​(Cyclopropylmethyl)​-​4-​(4-​methoxybenzoyl)​-​N-​[(3,​5,​7,​8-​tetrahydro-​4-​oxo-​4H-​pyrano[4,​3-​d]​pyrimidin-​2-​yl)​methyl]​-​piperidineacetamide, NVP-TNKS 656, TNKS656
• 실험식(Hill 표기법): C₂₇H₃₄N₄O₅
• CAS Number: 1419949-20-4
• Molecular Weight: 494.58
• MDL number: MFCD28167762
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: N4(CCC(CC4)C(=O)c5ccc(cc5)OC)CC(=O)N(CC3CC3)Cc1[nH][c](c2c(n1)CCOC2)=O
• InChI: 1S/C27H34N4O5/c1-35-21-6-4-19(5-7-21)26(33)20-8-11-30(12-9-20)16-25(32)31(14-18-2-3-18)15-24-28-23-10-13-36-17-22(23)27(34)29-24/h4-7,18,20H,2-3,8-17H2,1H3,(H,28,29,34)
• InChI key: DYGBNAYFDZEYBA-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

NVP-TNKS656 is an orally active, highly potent and selective tankyrase inhibitor. NVP-TNKS656 is a potent antagonist of Wnt pathway that reverts resistance to PI3K and AKT inhibitors in treatment of colorectal cancer.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable