추천 제품
생물학적 소스
human
재조합
expressed in baculovirus infected Sf9 cells
분석
≥90% (SDS-PAGE)
형태
aqueous solution
분자량
29 kDa (Cyclin D1)
34 kDa (CDK4)
포장
pkg of 20 μg
solubility
water: soluble
NCBI 수납 번호
응용 분야
life science and biopharma
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... CCND1(595) , CDK4(1019)
일반 설명
Research area: Apoptosis
Cyclin D1 (CCND1) is a proto-oncogene. It is one of the three D-type cyclins. The gene encoding it is localized on human chromosome 11q13. Cyclin dependent kinase-like 4 (CDKL4) is part of the cyclin-dependent protein kinase (CDK) family. The gene encoding it is localized on human chromosome 12q14-15.
Cyclin D1 (CCND1) is a proto-oncogene. It is one of the three D-type cyclins. The gene encoding it is localized on human chromosome 11q13. Cyclin dependent kinase-like 4 (CDKL4) is part of the cyclin-dependent protein kinase (CDK) family. The gene encoding it is localized on human chromosome 12q14-15.
Recombinant, full length human CDK4 (Genbank Accession No. NM_000075), amino acids 16-271, with C-terminal His-tag and modifications (amino acids 43G-47G were replaced with EE, and T172A), MW=34 kDa, and human Cyclin D1 (Genbank accession number NM_053056), MW 29 kDa, were co-expressed in a Baculovirus-infected Sf9 cells expression system.
생화학적/생리학적 작용
Cyclin D1 (CCND1) regulates the Wnt signaling pathway. It also regulates the progression of the cell cycle from the G1 to S phase in many cell types. CCND1 phosphorylates and inactivates retinoblastoma (Rb) protein. Cyclin D1 has been associated with mantle cell lymphoma. This protein is overexpressed in multiple cancers like hepatocellular carcinoma. Cyclin dependent kinase-like 4 (CDKL4) has been associated with various tumors and colorectal cancer. The protein regulates apoptosis of nucleated cells by modifying transcriptional regulation of genes governing cell proliferation and cell death. Like CCND1, it also modulates the progression of cycle from G1 to S phase.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Impact of cyclin-dependent kinase CDK4 inhibition on eryptosis.
Cellular Physiology and Biochemistry, 37(3), 1178-1186 (2015)
Association Between Polymorphism rs678653 in Human Cyclin D1 Gene (CCND1) and Susceptibility to Cancer: A Meta-Analysis
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 22, 863-874 (2016)
miR-16 induction after CDK4 knockdown is mediated by c-Myc suppression and inhibits cell growth as well as sensitizes nasopharyngeal carcinoma cells to chemotherapy.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(2), 2425-2433 (2016)
Bioinformatics prediction and experimental validation of microRNA-20a targeting Cyclin D1 in hepatocellular carcinoma
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(4) (2017)
Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: The ?missing link? between lipomas and liposarcomas?
Cancer Genetics, 121(2), 308-315 (2007)
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